|
KMID : 0355820140350010011
|
|
Korean Journal of Oral Anatomy
2014 Volume.35 No. 1 p.11 ~ p.21
|
|
|
Indirubin-3-monoxime inhibits excitotoxicity provoked by glutamate on neuroblastoma cell culture
|
|
Han Seung-Yun
Jung Bo-Hyun
Lee Hee-Su
Yoo Ki-Yeon
|
|
|
Abstract
|
|
|
|
Indirubin is the active component of Danggui Luhui Wan, a Chinese traditionally medicine. Recently, pharmaceutical researches have focused on its inhibitory effect of cyclin-dependent kinases (Cdks) and glycogen synthase kinase~3beta (GSK3"). Indirubin-3’-monoxime (IMX), a synthetic derivative by indirubin, is commonly used to in vitro studies for indirubin. In the present study, we investigated the inhibitory effect of IMX on glutamate-induced excitotoxicity in human neuroblastoma SH-SY5Y cells. Glutamate-induced cytotoxicity was verified characterized by decreased cell viability. However, treatment of IMX attenuated the glutamate-induced cell death in a dose-dependent manner. This result suggests that IMX may inhibit the neuronal death in various neurodegenerative diseases including stroke.
|
|
|
KEYWORD
|
|
|
indirubin-3'-monoxime, excitotoxicity, glutamate, SH-SY5Y
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
|